Slide preparation

For molecular diagnostics tests, tissue is macro-dissected from a number of unstained tissue slides. These slides are cut consecutively, starting with an H&E stained slide for reference.  All slides are barcoded and placed on a carrier that is inserted in the instrument.

Digitize all slides

Both the H&E stained and the dissection slides are scanned and all images are stored.

Pathology review & marking

All images are made available per case to the pathologist in a convenient interface for ROI selection and marking, supported by easy to use annotation tools.

Overlay slides

The marked ROIs are automatically transferred to the dissection slide images by using the latest image registration technologies. The result can be reviewed by the pathologist and corrected or rejected if necessary.

Tissue dissection

The robotic tissue dissector scrapes the tissue automatically from the dissection slides with high precision using a disposable knife. The knife dimensions and scrape paths are optimized for precision and throughput. Depending on the shape of the ROI typical throughput is 1 – 2 slides per minute. The accepted deviation of the ROI boundary is 0.1 mm. For each case a new knife is picked automatically.

Process output

The automatic tissue dissector transfers the tissue into small standard reagent tubes (e.g. Eppendorf) ready for the  molecular work up. No liquids are used in the process. Images are taken after scraping to check for the accuracy of the process. A report is generated including quality scores of the process.

Key benefits

  • High accuracy
  • High throughput
  • Full quality control
  • Reduced operational cost


Disposable 3
High position accuracy of < 0.1 mm
Xyall Tissector HT 20210325 01
Highly scalable throughput of up to 80 slides per hour
Xyall Motic Sep2020 V3
Full quality control: all cases are 100% traceable