At this year’s ECDP in Barcelona our CTO Reinhold Wimberger-Friedl presented a poster, showing first results of a joint investigation with LUMC with support of Indica Labs. Using digital annotation and robotic dissection led to a significant increase in tumor cellularity of the samples going into NGS as evident from the strong increase in Variant Allele Frequency (VAF) in the sequencing results compared to the routine manual workflow in the clinic. Very challenging core needle- and bronchial biopsies as well as fine needle aspirates (cytology) were processed successfully. AI-based tumor analysis helps in selecting the optimal regions of interest taking the dissectability requirements into account.